Last data update: May 13, 2024. (Total: 46773 publications since 2009)
Records 1-2 (of 2 Records) |
Query Trace: Zhang XY[original query] |
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Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis
Yao SQ , Rojanasakul LW , Chen ZY , Xu YJ , Bai YP , Chen G , Zhang XY , Zhang CM , Yu YQ , Shen FH , Yuan JX , Chen J , He QC . Apoptosis 2011 16 (12) 1195-204 In vitro and in vivo studies have demonstrated that lung cell apoptosis is associated with lung fibrosis; however the relationship between apoptosis of alveolar macrophages (AMs) and human silicosis has not been addressed. In the present study, AM apoptosis was determined in whole-lung lavage fluid from 48 male silicosis patients, 13 male observers, and 13 male healthy volunteers. The relationships between apoptosis index (AI) and silica exposure history, soluble Fas (sFas)/membrane-bound Fas (mFas), and caspase-3/caspase-8 were analyzed. AI, mFas, and caspase-3 were significantly higher in lung lavage fluids from silicosis patients than those of observers or healthy volunteers, but the level of sFas demonstrated a decreasing trend. AI was related to silica exposure, upregulation of mFas, and activation of caspase-3 and -8, as well as influenced by smoking status after adjusting for confounding factors. These results indicate that AM apoptosis could be used as a potential biomarker for human silicosis, and the Fas/FasL pathway may regulate this process. The present data from human lung lavage samples may help to understand the mechanism of silicosis and in turn lead to strategies for preventing or treating this disease. |
State-level socioeconomic factors are associated with current depression among U.S. adults in 2006 and 2008
Fan AZ , Strasser S , Zhang XY , Dhingra S , McKnight-Eily L , Holt J , Balluz L . J Public Health Epidemiol 2011 3 (10) 462-470 This study investigated whether state-level socioeconomic deprivation and income inequality are associated with depression prevalence. Current depressive symptoms within a two-week timeframe were assessed using the patient health questionnaire-2 from the 2006 and 2008 behavioral risk factor surveillance system (BRFSS) administered in selected states. State socio-economic deprivation indexes (percent of people below poverty level; employment/population ratio for the population 16 to 64 years old; median household income) were obtained from the 2006 and 2008 American community survey (ACS). State Gini indexes (indicating income inequality) were obtained from 2000 U.S. Census. After controlling for age, sex, race/ethnicity, marital status, educational attainment, annual household income, and chronic physical health condition index, adults residing in states with median household income in the lowest quintile (OR (95% CI)=1.18 (1.16 to 1.20) vs. others), in states with population below poverty line greater than the fourth quintile (OR (95% CI)=1.22 (1.20 to 1.24), vs. others), in states with employment/population ratios in the lowest quintile (OR(95% CI)=1.31 (1.29 to 1.34), vs. others), and in states with higher income inequality (GINI index >0.452) (OR(95% CI)=1.22 (1.21-1.24), vs. others) had higher odds of current depression. The results suggest that state-level socioeconomic factors are associated with depression prevalence among U.S. adults beyond individual level socioeconomic characteristics. |
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